Angiomatoid fibrous histiocytoma: Clinicopathological spectrum of five cases, including EWSR1-CREB1 positive result in a single case
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چکیده
منابع مشابه
Endobronchial pulmonary angiomatoid fibrous histiocytoma: two cases with EWSR1-CREB1 and EWSR1-ATF1 fusions.
Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue neoplasm of intermediate biological potential, predominantly occurring in the extremities of children and young adults. It has only recently been reported as a primary lung tumor. We describe 2 cases arising endobronchially harboring EWSR1 gene rearrangements by fluorescence in situ hybridization and, respectively, EWSR1-CREB1 and EWS...
متن کاملEWSR1-CREB1 and EWSR1-ATF1 fusion genes in angiomatoid fibrous histiocytoma.
PURPOSE Angiomatoid fibrous histiocytoma (AFH) is a low-grade mesenchymal neoplasm which usually occurs in children and adolescents. Either FUS-ATF1 or EWSR1-ATF1 have been detected in the few cases published, pointing to the interchangeable role of FUS and EWSR1 in this entity. EWSR1-ATF1 also represents the most frequent genetic alteration in clear cell sarcoma, suggesting the existence of a ...
متن کاملCervical Angiomatoid Fibrous Histiocytoma
Background: Angiomatoid fibrous histiocytoma (AFH) is a rare type of sarcoma with low-grade malignancy that usually occurs in young subjects. AFH is uncommon in the head and neck region. Methods: We describe an exceptional case of localization in the neck. This is the first report of a rare variant of AFH presenting in a 42-year-old woman. The tumor was situated posterior to the carotid artery ...
متن کاملClinicopathological features of angiomatoid fibrous histiocytoma: a series of 21 cases with variant morphology.
We analyzed the clinicopathological features of angiomatoid fibrous histiocytoma (AFH) in 21 cases with emphasis on variant morphology. In our series, ten patients were male and eleven were female. The patients' mean age was 26.9 years old. Tumors were located on the lower limbs in eight cases, upper limbs in three, trunk in five, head and neck in four, and trachea in one. Microscopically, thir...
متن کاملAneurysmal ("angiomatoid") fibrous histiocytoma in a child.
A case of aneurysmal ("angiomatoid") fibrous histiocytoma (AFH) in a 12-year-old girl is presented with its unusual clinicopathologic features. The lesion had the full microscopic characteristics of AFH described in prior reports, but it also had some features that differed from the original description of the disorder, such as the involvement of subcutis, its occurrence in the scalp, and a doc...
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ژورنال
عنوان ژورنال: Indian Journal of Pathology and Microbiology
سال: 2016
ISSN: 0377-4929
DOI: 10.4103/0377-4929.182023